Combined action of sulfadiazine and trimethoprim

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Combined action of sulfadiazine and trimethoprim.

It has been claimed that trimethoprim, 2,4diamino 5 (3',4',5' trimethoxybenzyl)pyrimidine, exerts a "synergistic" effect when combined with sulfonamides (Hitchings, Drugs, Parasites and Hosts, p. 202, J. and A. Churchill, Ltd., London, 1962) and polymyxin (Garrod and Waterworth, J. Clin. Pathol. 15:328, 1962) in experimental infection of mice and natural 0.5 ml of a 5% suspension of granular ho...

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Occurrence and Dissipation of the Antibiotics Sulfamethoxazole, Sulfadiazine, Trimethoprim, and Enrofloxacin in the Mekong Delta, Vietnam

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Short-term Results of Two Treatment Regimens in Ocular Toxoplasmosis: Trimethoprim/Sulfamethoxazole versus Pyrimethamine and Sulfadiazine

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Mechanism of silver sulfadiazine action on burn wound infections.

The role of silver and sulfadiazine in the mechanism of action of silver sulfadiazine on burn wound infections was investigated. Silver, but not sulfadiazine, was bound by bacteria. Sulfadiazine did not act as an antibacterial agent in low concentrations, but exhibited specific synergism in combination with subinhibitory levels of silver sulfadiazine. The efficacy of silver sulfadiazine is thou...

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ژورنال

عنوان ژورنال: Applied Microbiology

سال: 1966

ISSN: 0003-6919

DOI: 10.1128/am.14.2.299-300.1966